Last tested: Aug 23, 2019
You bet! Even though you probably don't want to load a topoJSON larger than 5mb directly into the IDE (or the browser), there's a straightforward way to utilize large map layers in Looker, only downloading the bits you need at any given time to keep things manageable.
Procedure is outlined here:
https://community.looker.com/dashboards-looks-7/large-custom-map-layers-with-tiles-13454This content is subject to limited support.